Publications
2015
Sclerostin Immunoreactivity Increases in Cortical Bone Osteocytes and Decreases in Articular Cartilage Chondrocytes in Aging Mice. Thompson ML, Jimenez-Andrade JM, Mantyh PW. Journal of Histochemistry & Cytochemistry. 2015 Dec 23. PMID: 26701970
Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer. Thompson ML, Jimenez-Andrade JM, Chartier S, Tsai J, Burton EA, Habets G, Lin PS, West BL,Mantyh PW. Pain. 2015 Sep PMID: 25993548
Spinal Dopaminergic Projections Control the Transition to Pathological Pain Plasticity via a D1/D5-Mediated Mechanism. Kim JY, Tillu DV, Quinn TL, Mejia GL, Shy A, Asiedu MN, Murad E, Schumann AP, Totsch SK, Sorge RE, Mantyh PW, Dussor G, Price TJ. J Neurosci. 2015 Apr 22. PMID: 25904784
Orthopedic surgery and bone fracture pain are both significantly attenuated by sustained blockade of nerve growth factor. Majuta LA, Longo G, Fealk MN, McCaffrey G, Mantyh PW. Pain. 2015 Jan. PMID: 25599311
2014
NGF blockade at early times during bone cancer development attenuates bone destruction and increases limb use.McCaffrey G, Thompson ML, Majuta L, Fealk MN, Chartier S, Longo G, Mantyh PW. Cancer Res. 2014 Dec 1. Epub 2014 Oct 6. PMID: 25287160
Exuberant sprouting of sensory and sympathetic nerve fibers in nonhealed bone fractures and the generation and maintenance of chronic skeletal pain. Chartier SR, Thompson ML, Longo G, Fealk MN, Majuta LA, Mantyh PW. Pain. 2014 Nov. Epub 2014 Sep 6. PMID: 25196264
Bone cancer pain: from mechanism to therapy.Mantyh PW. Curr Opin Support Palliat Care. 2014 Jun;8(2):83-90. doi:10.1097/SPC.0000000000000048. Review. PMID: 24792411
The ACTTION-American Pain Society Pain Taxonomy (AAPT): an evidence-based and multidimensional approach to classifying chronic pain conditions. Fillingim RB, Bruehl S, Dworkin RH, Dworkin SF, Loeser JD, Turk DC, Widerstrom-Noga E, Arnold L, Bennett R, Edwards RR, Freeman R, Gewandter J, Hertz S, Hochberg M, Krane E, Mantyh PW, Markman J, Neogi T, Ohrbach R, Paice JA, Porreca F, Rappaport BA, Smith SM, Smith TJ, Sullivan MD, Verne GN, Wasan AD, Wesselmann U.J Pain. 2014 Mar. PMID: 24581634
The neurobiology of skeletal pain.Mantyh PW. Eur J Neurosci. 2014 Feb;39(3):508-19. doi: 10.1111/ejn.12462. Review. PMID: 24494689
2013
Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists. Lozano-Ondoua AN, Hanlon KE, Symons-Liguori AM, Largent-Milnes TM, Havelin JJ, Ferland HL 3rd, Chandramouli A, Owusu-Ankomah M, Nikolich-Zugich T, Bloom AP, Jimenez-Andrade JM, King T, Porreca F, Nelson MA, Mantyh PW, Vanderah TW.J Bone Miner Res. 2013 Jan;28(1):92-107. doi: 10.1002/jbmr.1732. PMID: 22903605
2012
Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint. Ghilardi JR, Freeman KT, Jimenez-Andrade JM, Coughlin KA, Kaczmarska MJ, Castaneda-Corral G, Bloom AP, Kuskowski MA, Mantyh PW. Arthritis Rheum. 2012 Jul;64(7):2223-32. doi: 10.1002/art.34385. PMID: 22246649
The effect of aging on the density of the sensory nerve fiber innervation of bone and acute skeletal pain. Jimenez-Andrade JM, Mantyh WG, Bloom AP, Freeman KT, Ghilardi JR, Kuskowski MA, Mantyh PW. Neurobiol Aging. 2012 May;33(5):921-32. doi: 10.1016/j.neurobiolaging.2010.08.008. Epub 2010 Oct 13. PMID: 20947214
Sensory and sympathetic nerve fibers undergo sprouting and neuroma formation in the painful arthritic joint of geriatric mice. Jimenez-Andrade JM, Mantyh PW. Arthritis Res Ther. 2012 May 1;14(3):R101. doi: 10.1186/ar3826. PMID: 22548760
2011
Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain. Jimenez-Andrade JM, Ghilardi JR, Castañeda-Corral G, Kuskowski MA, Mantyh PW. Pain. 2011 Nov;152(11):2564-74. doi: 10.1016/j.pain.2011.07.020. Epub 2011 Sep 9. PMID: 21907491
Antagonism of nerve growth factor-TrkA signaling and the relief of pain. Mantyh PW, Koltzenburg M, Mendell LM, Tive L, Shelton DL. Anesthesiology. 2011 Jul;115(1):189-204. doi: 10.1097/ALN.0b013e31821b1ac5. PMID: 21602663
Breast cancer-induced bone remodeling, skeletal pain, and sprouting of sensory nerve fibers. Bloom AP, Jimenez-Andrade JM, Taylor RN, Castañeda-Corral G, Kaczmarska MJ, Freeman KT, Coughlin KA, Ghilardi JR, Kuskowski MA, Mantyh PW. J Pain. 2011 Jun;12(6):698-711. doi: 10.1016/j.jpain.2010.12.016. Epub 2011 Apr 15. PMID: 21497141
The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A. Castañeda-Corral G, Jimenez-Andrade JM, Bloom AP, Taylor RN, Mantyh WG, Kaczmarska MJ, Ghilardi JR, Mantyh PW. Neuroscience. 2011 Mar 31;178:196-207. doi: 10.1016/j.neuroscience.2011.01.039. Epub 2011 Jan 26. PMID: 21277945
Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers. Ghilardi JR, Freeman KT, Jimenez-Andrade JM, Mantyh WG, Bloom AP, Bouhana KS, Trollinger D, Winkler J, Lee P, Andrews SW, Kuskowski MA, Mantyh PW. Bone. 2011 Feb;48(2):389-98. doi: 10.1016/j.bone.2010.09.019. Epub 2010 Sep 18. PMID: 20854944
2010
Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain. Ghilardi JR, Freeman KT, Jimenez-Andrade JM, Mantyh WG, Bloom AP, Kuskowski MA, Mantyh PW. Mol Pain. 2010 Dec 7;6:87. doi: 10.1186/1744-8069-6-87. PMID: 21138586
Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain. Mantyh WG, Jimenez-Andrade JM, Stake JI, Bloom AP, Kaczmarska MJ, Taylor RN, Freeman KT, Ghilardi JR, Kuskowski MA, Mantyh PW. Neuroscience. 2010 Dec 1;171(2):588-98. doi: 10.1016/j.neuroscience.2010.08.056. Epub 2010 Sep 20. PMID: 20851743
Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain. Jimenez-Andrade JM, Bloom AP, Stake JI, Mantyh WG, Taylor RN, Freeman KT, Ghilardi JR, Kuskowski MA, Mantyh PW. J Neurosci. 2010 Nov 3;30(44):14649-56. doi: 10.1523/JNEUROSCI.3300-10.2010. PMID: 21048122
Bone cancer pain. Jimenez-Andrade JM, Mantyh WG, Bloom AP, Ferng AS, Geffre CP, Mantyh PW. Ann N Y Acad Sci. 2010 Jun;1198:173-81. doi: 10.1111/j.1749-6632.2009.05429.x. Review. PMID: 20536932
A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain. Jimenez-Andrade JM, Mantyh WG, Bloom AP, Xu H, Ferng AS, Dussor G, Vanderah TW, Mantyh PW. Bone. 2010 Feb;46(2):306-13. doi: 10.1016/j.bone.2009.09.013. Epub 2009 Sep 18. Erratum in: Bone. 2010 Jun;46(6):1670-1. PMID: 19766746
2009
Capsaicin-sensitive sensory nerve fibers contribute to the generation and maintenance of skeletal fracture pain. Jimenez-Andrade JM, Bloom AP, Mantyh WG, Koewler NJ, Freeman KT, Delong D, Ghilardi JR, Kuskowski MA, Mantyh PW. Neuroscience. 2009 Sep 15;162(4):1244-54. doi: 10.1016/j.neuroscience.2009.05.065. Epub 2009 May 29. PMID: 19486928
New advances in musculoskeletal pain. Bove SE, Flatters SJ, Inglis JJ, Mantyh PW. Brain Res Rev. 2009 Apr;60(1):187-201. doi: 10.1016/j.brainresrev.2008.12.012. Epub 2008 Dec 25. Review. PMID: 19166876
Vascularization of the dorsal root ganglia and peripheral nerve of the mouse: implications for chemical-induced peripheral sensory neuropathies. Jimenez-Andrade JM, Herrera MB, Ghilardi JR, Vardanyan M, Melemedjian OK, Mantyh PW. Mol Pain. 2008 Mar 19;4:10. doi: 10.1186/1744-8069-4-10. PMID: 18353190
2008
A fracture pain model in the rat: adaptation of a closed femur fracture model to study skeletal pain. Freeman KT, Koewler NJ, Jimenez-Andrade JM, Buus RJ, Herrera MB, Martin CD, Ghilardi JR, Kuskowski MA, Mantyh PW. Anesthesiology. 2008 Mar;108(3):473-83. doi: 10.1097/ALN.0b013e3181649351. PMID: 18292685
2007
Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture. Jimenez-Andrade JM, Martin CD, Koewler NJ, Freeman KT, Sullivan LJ, Halvorson KG, Barthold CM, Peters CM, Buus RJ, Ghilardi JR, Lewis JL, Kuskowski MA, Mantyh PW. Pain. 2007 Dec 15;133(1-3):183-96. Epub 2007 Aug 10. PMID: 17693023
Organization of a unique net-like meshwork of CGRP+ sensory fibers in the mouse periosteum: implications for the generation and maintenance of bone fracture pain. Martin CD, Jimenez-Andrade JM, Ghilardi JR, Mantyh PW. Neurosci Lett. 2007 Nov 12;427(3):148-52. Epub 2007 Sep 1. PMID: 17950532
Cancer pain and its impact on diagnosis, survival and quality of life. Mantyh PW. Nat Rev Neurosci. 2006 Oct;7(10):797-809. Review. PMID: 16988655
An evolving cellular pathology occurs in dorsal root ganglia, peripheral nerve and spinal cord following intravenous administration of paclitaxel in the rat. Peters CM, Jimenez-Andrade JM, Kuskowski MA, Ghilardi JR, Mantyh PW. Brain Res. 2007 Sep 7;1168:46-59. Epub 2007 Jul 17. PMID: 17698044
The cerebral signature for pain perception and its modulation. Tracey I, Mantyh PW. Neuron. 2007 Aug 2;55(3):377-91. Review. PMID: 17678852
Effects of a monoclonal antibody raised against nerve growth factor on skeletal pain and bone healing after fracture of the C57BL/6J mouse femur. Koewler NJ, Freeman KT, Buus RJ, Herrera MB, Jimenez-Andrade JM, Ghilardi JR, Peters CM, Sullivan LJ, Kuskowski MA, Lewis JL, Mantyh PW. J Bone Miner Res. 2007 Nov;22(11):1732-42. PMID: 17638576
Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells. Peters CM, Jimenez-Andrade JM, Jonas BM, Sevcik MA, Koewler NJ, Ghilardi JR, Wong GY, Mantyh PW. Exp Neurol. 2007 Jan;203(1):42-54. Epub 2006 Sep 26. PMID: 17005179
2006
Endogenous opioids inhibit early-stage pancreatic pain in a mouse model of pancreatic cancer. Sevcik MA, Jonas BM, Lindsay TH, Halvorson KG, Ghilardi JR, Kuskowski MA, Mukherjee P, Maggio JE, Mantyh PW. Gastroenterology. 2006 Sep;131(3):900-10. PMID: 16952558
Similarities and differences in tumor growth, skeletal remodeling and pain in an osteolytic and osteoblastic model of bone cancer. Halvorson KG, Sevcik MA, Ghilardi JR, Rosol TJ, Mantyh PW. Clin J Pain. 2006 Sep;22(7):587-600. Review. PMID: 16926574